Title: N6-methyladenosine modifications stabilize phosphate starvation response–related mRNAs in plant adaptation to nutrient-deficient stress
Kai Liu, Xiaojia Wang, Jingyi Wang, Shuman Wang, Haiyan Bai, Weiguo Dong, Lulu Qiao, Qiongli Jin, Zhonghui Zhang, Guan-Zheng Luo, Zhiye Wang
Abstract
Phosphorus (P) is an essential macronutrient for plant growth. However, the availability of inorganic phosphate (Pi) in soils is generally low, and Pi is readily immobilized, leading to frequent phosphorus deficiency in plants during their growth. In-depth research on the mechanisms of plant responses to phosphate starvation, and improving phosphorus uptake and utilization efficiency, are of great significance for achieving sustainable agricultural development. The research group of Zhiye Wang at the College of Life Sciences, Zhejiang University has long been dedicated to studying plant nutrient stress resistance mechanisms at the level of RNA metabolism. N⁶-methyladenosine (m⁶A) is the most abundant internal modification in eukaryotic mRNA and plays important roles in post-transcriptional regulation and translation. Previous studies have indicated that m⁶A serves important regulatory functions in plant responses to various stresses. However, the molecular mechanisms by which m⁶A participates in regulating plant responses to phosphate starvation remain unclear.
Link: https://www.nature.com/articles/s41467-025-59331-y
