Publication in Molecular Biomedicine by Prof. ZHU Chenggang's Laboratory, Institute of Biochemistry
College of Life Sciences, Zhejiang University
Title: ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2Yifei Wang, Jinghan Xu, Yiquan Chen, Xin Xiao, Yiru Zhu, Liyang Yu, Wen Shi, Jingchao Li, Jianhua Li and Chenggang ZhuAbstractThe COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current a...
Publication in Advanced Science by Prof. WANG Yong's Laboratory, Institute of Biophysics
College of Life Sciences, Zhejiang University
Title: AI-Physics-Experiment Trinity for Integrated Protein Dynamics ModelingChen Shi, Minying Low, Peng Xiu, Kresten Lindorff-Larsen, Yong WangAbstractProteins exist as conformational ensembles, with dynamic transitions governing biological processes. Deciphering these dynamics demands integrating experimental data, physics‐based simulations, and artificial intelligence (AI)—each with distin...
Publication in Redox Biology by Prof. QIU Cong 's Laboratory, Institute of Genetics and Regenerative Biology
College of Life Sciences, Zhejiang University
Title: CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβYuanqing Jiang, Yi Li, Kefan Ma, Suxiang Guo, Nachuan Liao ,Jiayi Zhou, Junbo Chen, Ruizhe Ren, Yaohui Kou, Jinying Li, He Liu, Yang Wei, Xiaofei Zhou, Linge Fan, Lingfeng Qin, Haige Zhao, Ying Xiao, Luyang Yu, Zhen Ge, Cong Q...
Publication in Advanced Science by Prof. JIANG Hui's Laboratory, Institute of Biochemistry
College of Life Sciences, Zhejiang University
Title: Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram-Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui JiangAbstractNonribosomal peptide (NRP) antibiotics exhibit potent biological activities and are broadly used...
Publication in Plant Cell by Prof. WANGZhiye's Laboratory, Institute of Botany
College of Life Sciences, Zhejiang University
Title: Improving low-phosphate tolerance via tissue-specific CRISPR/Cas9 knockout to balance growth and stress responses in riceGuangbo Wei , Zhengwei Huang , Shuman Wang, Fangzhou Zheng , Jiakai Yao , Qiongli Jin , Youchao Zhang , Hongli Luo , Xinlian Zhang , Yichen He , Mingchuan Zhou , ...
Publication in Nucleic Acids Research by Prof. Chen Ming 's Laboratory, Institute of Bioinformatics
College of Life Sciences, Zhejiang University
Title:T2T-Hub: a central platform for analyzing plant and animal telomere-to-telomere genomesHaoyu chao, Zhonghao Ruan, Zhuojin Li, Xinkai Zhou, Shilong Zhang, Xingxing Shen, Cong Feng, Dijun Chen, Ming ChenAbstractT2T-Hub is a free, web-based platform designed to facilitate the analysis and visualization of telomere-to-telomere (T2T) genomes in plants and animals. The server integrates automated ...
Publication in Nature Communications by Prof. JianXiang Liu's Laboratory, Institute of Plant Biology
College of Life Sciences, Zhejiang University
Title: Signal peptide peptidase like proteases OsSPPL1 and OsSPPL2 facilitate ER-associated protein degradation in riceHai-Ping Lu, Jian-Hang Xu, Jia-Xin Chang, Hui-Dan Luo & Jian-Xiang LiuAbstractSignal peptide peptidases (SPPs) play a critical role in intramembrane proteolysis of signal peptides in mammals. However, their function in plants remains poorly understood. Here, we uncover the cri...
Publication in JOURNAL OF HEPATOLOGY by Prof. YANG Weijun's Laboratory, Institute of Cell
College of Life Sciences, Zhejiang University
Title: Setd4-expressing cells drive regenerative recovery in chronic liver injuryXi-Zheng Jia, Tian-Tian Zhuang, Ri-Sheng Yang, Yun-Wen Gu, Yi-Zhe Zeng, Christopher Wood, Jin-Shu Yang, Wei-Jun YangAbstractAs the metabolic center of the body, the liver is susceptible to chronic damage from toxic metabolites or exogenous substances, leading to the apoptosis of hepa...
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