Publication in Cell Research by Prof. WANG Yong's Laboratory, Institute of Biophysics
.01, 2023
College of Life Sciences, Zhejiang University
Title: Structure and transport mechanism of the human calcium pump SPCA1Mengqi Wu, Cang Wu, Tiefeng Song, Kewu Pan, Yong Wang & Zhongmin LiuAbstractSecretory-pathway Ca2+-ATPases (SPCAs) play critical roles in maintaining Ca2+ homeostasis, but the exact mechanism of SPCAs-mediated Ca2+ transport remains unclear. Here, we determined six cryo-electron microscopy (cryo-EM) structures of huma...
Publication in Nature by Prof. ZHOU Ruhong's Laboratory, Institute of Biophysics
.27, 2023
College of Life Sciences, Zhejiang University
Title: Structural basis of BAM-mediated outer membrane β-barrel protein assemblyChongrong Shen, Shenghai Chang, Qinghua Luo, Kevin Chun Chan, Zhibo Zhang, Bingnan Luo, Teng Xie, Guangwen Lu, Xiaofeng Zhu, Xiawei Wei, Changjiang Dong, Ruhong Zhou, Xing Zhang, Xiaodi Tang & Haohao DongAbstractThe outer membrane structure is common in Gram-negative bacteria, mitochondria and chloroplasts, and co...
Publication in Nature Communications by Prof. LIN Aifu's Laboratory, Institute of Genetics and Regenerative Biology
.24, 2023
College of Life Sciences, Zhejiang University
Title: LncRNA modulates Hippo-YAP signaling to reprogram iron metabolismXin-yu He, Xiao Fan, Lei Qu, Xiang Wang, Li Jiang, Ling-jie Sang, Cheng-yu Shi, Siyi Lin, Jie-cheng Yang, Zuo-zhen Yang, Kai Lei, Jun-hong Li, Huai-qiang Ju, Qingfeng Yan, Jian Liu, Fudi Wang, Jianzhong Shao, Yan Xiong, Wenqi Wang & Aifu LinAbstractIron metabolism dysregulation is tightly associated with cancer development...
Publication in Nature Communications by Prof. WANG Yong's Laboratory, Institute of Biophysics
.13, 2023
College of Life Sciences, Zhejiang University
Title: Conformational cycle of human polyamine transporter ATP13A2Jianqiang Mu, Chenyang Xue, Lei Fu, Zongjun Yu, Minhan Nie, Mengqi Wu, Xinmeng Chen, Kun Liu, Ruiqian Bu, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Kevin C. Chan, Ruhong Zhou, Huilin Li, Ancheng Huang, Yong Wang & Zhongmin LiuAbstractDysregulation of polyamine homeostasis strongly associates with human diseases...
Publication in PNAS by Prof. ZHOU Ruhong's Laboratory, Institute of Biophysics
.13, 2023
College of Life Sciences, Zhejiang University
Title: A mutagenesis study of autoantigen optimization for potential T1D vaccine designYi Song, David R. Bell, Rizwan Ahmed, Kevin C. Chan, Sangyun Lee, Abdel Rahim A. Hamad, and Ruhong ZhouAbstractA previously reported autoreactive antigen, termed the X-idiotype, isolated from a unique cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells. This antigen was p...
Publication in Molecular Plant by Dr. DU Juan's Laboratory, Institute of Plant Biology
.03, 2023
College of Life Sciences, Zhejiang University
Title: High-resolution anatomical and spatial transcriptome analyses reveal two types of meristematic cell pools within the secondary vascular tissue of poplar stemJuan Du, Yichen Wang, Wenfan Chen, Mingling Xu, Ruhong Zhou, Huixia Shou, Jun ChenAbstractThe secondary vascular tissue emanating from meristems is central to understanding how vascular plants such as forest trees evolve, grow, and regu...
Publication in PNAS by Prof. YI Wen's Laboratory, Institute of Biochemistry
.27, 2023
College of Life Sciences, Zhejiang University
Title: O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradationQiang Zhu, Hongxing Wang, Siyuan Chai, Liang Xu, Bingyi Lin, Wen Yi, and Liming WuAbstractProgrammed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) mediate T cell–dependent immunity against tumors. The abundance of cell surface PD-L1 is a key determinant of the efficacy of immune c...
Publication in PNAS by Prof. LIN Aifu's Laboratory, Institute of Genetics and Regenerative Biology
.20, 2023
College of Life Sciences, Zhejiang University
Title: lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, and Aifu LinAbstractNotch has been implicated in human cancers and is a putat...
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