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homepage  RESEARCH  Latest Scientific Research
  • Publication in Nature Communications by Prof. LIN Aifu's Laboratory, Institute of Genetics and Regenerative Biology .24, 2023 College of Life Sciences, Zhejiang University Title: LncRNA modulates Hippo-YAP signaling to reprogram iron metabolismXin-yu He, Xiao Fan, Lei Qu, Xiang Wang, Li Jiang, Ling-jie Sang, Cheng-yu Shi, Siyi Lin, Jie-cheng Yang, Zuo-zhen Yang, Kai Lei, Jun-hong Li, Huai-qiang Ju, Qingfeng Yan, Jian Liu, Fudi Wang, Jianzhong Shao, Yan Xiong, Wenqi Wang & Aifu LinAbstractIron metabolism dysregulation is tightly associated with cancer development...
  • Publication in Nature Communications by Prof. WANG Yong's Laboratory, Institute of Biophysics .13, 2023 College of Life Sciences, Zhejiang University Title: Conformational cycle of human polyamine transporter ATP13A2Jianqiang Mu, Chenyang Xue, Lei Fu, Zongjun Yu, Minhan Nie, Mengqi Wu, Xinmeng Chen, Kun Liu, Ruiqian Bu, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Kevin C. Chan, Ruhong Zhou, Huilin Li, Ancheng Huang, Yong Wang & Zhongmin LiuAbstractDysregulation of polyamine homeostasis strongly associates with human diseases...
  • Publication in PNAS by Prof. ZHOU Ruhong's Laboratory, Institute of Biophysics .13, 2023 College of Life Sciences, Zhejiang University Title: A mutagenesis study of autoantigen optimization for potential T1D vaccine designYi Song, David R. Bell, Rizwan Ahmed, Kevin C. Chan, Sangyun Lee, Abdel Rahim A. Hamad, and Ruhong ZhouAbstractA previously reported autoreactive antigen, termed the X-idiotype, isolated from a unique cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells. This antigen was p...
  • Publication in Molecular Plant by Dr. DU Juan's Laboratory, Institute of Plant Biology .03, 2023 College of Life Sciences, Zhejiang University Title: High-resolution anatomical and spatial transcriptome analyses reveal two types of meristematic cell pools within the secondary vascular tissue of poplar stemJuan Du, Yichen Wang, Wenfan Chen, Mingling Xu, Ruhong Zhou, Huixia Shou, Jun ChenAbstractThe secondary vascular tissue emanating from meristems is central to understanding how vascular plants such as forest trees evolve, grow, and regu...
  • Publication in PNAS by Prof. YI Wen's Laboratory, Institute of Biochemistry .27, 2023 College of Life Sciences, Zhejiang University Title: O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradationQiang Zhu, Hongxing Wang, Siyuan Chai, Liang Xu, Bingyi Lin, Wen Yi, and Liming WuAbstractProgrammed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) mediate T cell–dependent immunity against tumors. The abundance of cell surface PD-L1 is a key determinant of the efficacy of immune c...
  • Publication in PNAS by Prof. LIN Aifu's Laboratory, Institute of Genetics and Regenerative Biology .20, 2023 College of Life Sciences, Zhejiang University Title: lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, and Aifu LinAbstractNotch has been implicated in human cancers and is a putat...
  • Publication in Methods in Nature Ecology & Evolution by Prof. DING Ping's Laboratory, Institute of Ecology .03, 2023 College of Life Sciences, Zhejiang University Title: Forest edges increase pollinator network robustness to extinction with declining areaPeng Ren, Raphael K. Didham, Mark V. Murphy, Di Zeng, Xingfeng Si & Ping DingAbstractEdge effects often exacerbate the negative effects of habitat loss on biodiversity. In forested ecosystems, however, many pollinators actually prefer open sunny conditions created by edge disturbances. We tested the hyp...
  • Publication in Methods in Ecology and Evolution by Prof. DING Ping's Laboratory, Institute of Ecology .10, 2023 College of Life Sciences, Zhejiang University Title: An integrated animal tracking technology combining a GPS tracking system with a UAVTinghao Jin, Xingfeng Si, Juan Liu, Ping DingFirst published: 30 December 2022Abstract1.       Global Position System (GPS) tags are widely used in animal tracking to address far-ranging ecological, behavioural and conservation-related questions. However, GPS tags with transmitti...
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